Dr. Caleb Kesse Firempong

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Caleb Kesse Firempong, PhD

Senior Lecturer

Phone #:+233-20-8243995

Email: ckfirempong.cos@knust.edu.gh / calebuse@yahoo.com

EDUCATION AND EXPERIENCE

2015.7- Date            Research Collaborator, Department of Pharmaceutics, School of Pharmacy, Jiangsu

                                University China.

2012.1.-2015.6        PhD, Medical Science and Laboratory diagnostics, Jiangsu University, China.

2001.8-2004.5        MPhil., Biochemistry, Kwame Nkrumah University of Science and Technology

                               (KNUST), Kumasi-Ghana.

1996.8-2000.5        BSc., Biochemistry, University of Ghana, Legon.

RESEARCH INTEREST

1. Cancer drug discovery from natural products -Isolation, identification, formulation and mechanistic action of active agents.
2. High-throughput screening and formulation development of active components from Ghanaian Medicinal Herbs.
3. Biochemical analysis and management of genetic disorders - G6PD Deficiency and Sickle Cell Disorders.

ONGOING PROJECTS

1. Lipid rafts silica beads for screening anti-tumor agents from Ghanaian Medicinal Herbs.
2. Screening of hepatoprotective active components from natural products.
3. Diseases related to dietary intake and lifestyle pattern- Cardiovascular Diseases and Diabetes.
4. Treatment of Sickle Cell Diseases using natural products.

SELECTED PUBLICATIONS

1. Caleb Kesse Firempong, Kwabena Nsiah, Francis Agyemang Yeboah. Some clinical and haematological effect of G6PD deficiency among individuals with sickle cell disorders in Kumasi, Ghana. The Journal of Medical Research. 2016:  2 (3): 81-85.
2. C. K. Firempong, L.A. Andoh., W.G. Akanwariwiak, P. Addo-Fordjour, P. Adjakofi. Phytochemical screening and antifungal activities of crude ethanol extracts of red-flowered silk cotton tree (Bombax buonopozense) and Calabash nutmeg (Monodora myristica) on Candida albicans. Journal of Microbiology and Antimicrobials. 2016: 8 (4): 22-27.
3. Caleb Kesse Firempong, Hui Yun Zhang, Yan Wang, Jingjing Chen , Xia Cao,  Jie Zhou, Qiang Wang, Shan-Shan Tong, Jiangnan Yu and Ximing Xu. Segetoside I, a plant-derived bisdesmosidic saponin, induces apoptosis in human hepatoma cells in vitro and inhibits tumor growth in vivo. Pharmacological Research. 2016. DOI: 10.1016/j.phrs.2016.04.032 (SCI, IF =4.4 1) 
4. Huiyun Zhang, Caleb Kesse Firempong, Yuanwen Wang, Wenqian Xu, Miaomiao Wang, Xia-Cao, Yuan Zhu, Shanshan Tong, Jiangnan Yu and Ximing Xu. Enhanced in vitro antitumor activity and oral bioavailability of ergosterol-loaded poly(lactide-co-glycolide) nanoparticles. Acta Pharmacologica sinica. 2016. (SCI, IF =3.16)
5. Wang Yuanwen, Shicheng Wang, Caleb Kesse Firempong, Huiyun Zhang, Miaomiao Wang, Ya Zhang, Yuan Zhu, Jiangnan Yu, and Ximing Xu. "Enhanced Solubility and Bioavailability of Naringenin via Liposomal Nanoformulation: Preparation and In Vitro and In Vivo Evaluations." AAPS PharmSciTech (2016): 1-9. (SCI, IF =1.6)
6. Omari-Siaw Emmanuel, Yuan Zhu, Houyong Wang, Wei Peng, Caleb Kesse Firempong, Yuan Wen Wang, Xia Cao, Wenwen Deng, Jiangnan Yu, and Ximing Xu. "Hypolipidemic potential of perillaldehyde-loaded self-nanoemulsifying delivery system in high-fat diet induced hyperlipidemic mice: Formulation, in vitro and in vivo evaluation." European Journal of Pharmaceutical Sciences 85 (2016): 112-122. (SCI, IF =3.35)
7. Feng, Yingshu, Congyong Sun, Yangyang Yuan, Yuan Zhu, Jinyi Wan, Caleb Kesse Firempong, Emmanuel Omari-Siaw et al. "Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation." International Journal of Pharmaceutics 501, no. 1 (2016): 342-349. (SCI, IF =3.65)
8. Shi Feng, Yingying Zhao, Caleb Kesse Firempong, and Ximing Xu. "Preparation, characterization and pharmacokinetic studies of linalool-loaded nanostructured lipid carriers." Pharmaceutical Biology (2016): 1-9. (SCI, IF =1.24)

POSITION AVAILABLE

MPhil/PhD in Biochemistry with background in Plant Biochemistry, Molecular Biology, Cell Biology, Pharmacognosy and Pharmacology.